As evidence, a major pharmaceutical company used an SSU in all of its U.S. Furthermore, the application functions as a single repository for in-progress documents, information only needs to be entered once, and documents from the principal investigator’s database and the investigator portal can be accessed via a single logon.Ĭollectively, these benefits are major timesavers in site activation. It is designed to provide better collaboration with sites and improve business processes (Chart 2). Using an application program interface (API), the solution can integrate with other eClinical operations-the “clinical stack”-to optimize the clinical trial continuum by allowing information to flow among the various integrated components (Figure 1). With the advent of purpose-built SSU solutions, real-time viewing of data and smart workflows that standardize processes becomes possible. ![]() A 2014 survey conducted by Veeva Systems found that 21 percent of CROs and 15 percent of sponsors use an eTMF application, and a content management system is used by roughly one-third of sponsors and CROs. According to the 2013 Clinical Trial Management Systems Survey by eCliniqua and BioClinica, some 60 percent of respondents use digital software, such as CTMS, to manage clinical trials. Fortunately, these inefficiencies can be eliminated, as a purpose-built SSU solution becomes the missing piece in a world of electronic tools that have been widely adopted for more efficient study conduct. As a result, time is wasted in status meetings, as the desired information is not readily available. This issue is complicated by the fact that information used to launch clinical trials typically resides in multiple databases, and SSU tends to be conducted using Excel spreadsheets, e-mail, and shared file drives. There are numerous challenges posed by the many steps involved in SSU, making study delay highly probable from the outset. clinical trial enterprise routinely fail to collect standardized measures of SSU cycle times, a practice that is common in many industries. That work identified seven SSU cycle times of interest (Chart 1), and concluded that many stakeholders in the U.S. Food and Drug Administration and undertaken by the Clinical Trial Transformation Initiative (CTTI). One of the early research efforts was funded by the U.S. To confront SSU issues in a way that engages clinical trial stakeholders, a collaborative approach has been deemed essential. Department of Health and Human Services names sponsor-imposed barriers to SSU such as overly complex internal review methods and highly restrictive inclusion/exclusion criteria as further slowing the SSU process. Moreover, a 2014 report funded by the U.S. These factors, plus poor case report form design, lack of recruitment planning, and not initiating sites in a timely fashion all contribute to delays. ![]() There is no standard definition of SSU, but activities such as country selection, pre-study visits, site selection and initiation, regulatory document submission, contract and budget execution, and enrolling the first patient are typically cited. There has been a strong focus on study conduct, but as stakeholders are increasingly aware that better SSU processes are linked to shorter clinical timelines, the emphasis is shifting in that direction. To confront these issues of cost and time, the industry has been evolving from its slow paper-based methods toward cloud-based systems. ![]() ![]() This approach leads to greater cost savings and faster market entry, making valuable therapies available to patients sooner.ĭaily revenue lost because a drug is not yet on the market has been estimated in the range of $1 million to $8 million, and data from the Tufts CSDD indicate that mean clinical development time is 6.7 years. Using cloud-based technology, a better SSU methodology aligns with the goal of faster development by significantly impacting cycle times. This article describes how the need for an improved SSU process is gaining traction. According to the Tufts Center for the Study of Drug Development (CSDD), it takes eight months to move from pre-visit through site initiation, and the cost of initiating one site has been estimated at $20,000 to $30,000, plus another $1,500 per month to maintain site oversight. The current status of clinical trials has encouraged stakeholders to embrace cloud-based solutions such as clinical trial management systems (CTMS), and the electronic trial master file (eTMF), but one key bottleneck, study startup (SSU), has been largely overlooked. There is intense pressure to speed clinical trials and restrain costs, but inefficiencies tied to complicated protocols, globalization, and paper-based methods have stalled these efforts.
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![]() Plus, you don’t even have to create a proposal format – just follow the instructions and document all of the necessary details, and this template will automatically push all of that information together in its final step to create your proposal. With room to record everything from your own details, to a summary of the project, all the way to the terms and conditions of the proposal, this has everything you need to create a job estimate for your client. General free estimate templates Process Street – Job Estimate Templateįirst up we have our very own job estimate template. Just head for one of the following sections and make your pick: All serve the purpose of giving your clients a professional job estimate document, but allowing you to just fill in basic details instead of creating each document from the ground up. ![]() Instead of having to create your own job estimate form, all you have to do is look through the templates below and see which one you like best. That’s why we here at Process Street have created and gathered these 14 free estimate templates. You don’t want to waste time filling out forms when you could be working, but any mistakes can severely damage your chances of getting the sale (if the estimate is too high) or even ruin your reputation (if the estimate is too low). Not only do you have to create an accurate estimate of how much everything will cost, but you have to do so as quickly as possible to have the best chance of securing the customer. ![]() The full crash report is obviously much longer) (below this message is same for Compressor.): If some is interested in part of the crash report for FCPX when selecting "Computer" (I replaced some ID's with "". Anyone else having a problem or hopefully a fix for this? 3126 14 I have talked to apple support and they did mostly things that I have already tried and no resolution has been found. But wanted to try to see if it was just the one machine or something else. I have a second imac and am having simuler problems with it on a trial basis as I normally do not use it for video editing. I make sure all apps are shut down which I never had to do before even to the point of going into activity monitor and shutting down things there. ![]() With faster decoding on multi-core, GPU, and mobile hardware and the ability to open more formats, notably professional, HD and 10bits codecs, 2.0 was a major upgrade for VLC. If you play with it and do a power management reset and every other thing you can think of you might get it done but it is hit or miss and mostly miss. 2.0.6 uses a new compiler for Windows version, done by the MinGW-w64 project. Never had a problem at all with the same machine and same file on High Sierra or before. It gives me a message saying I have run out of system memory. every time I try to import the file into imovie it gets to the end of the import and crashes. Almost same size every week and nothing changed. I have used this machine for over 3 years editing our church video services for youtube. Imovie crashes on mojave importing video I have a 27" imac 3.3 processor with 16 gig of ram. FCPX seemed to crash while trying to do something with the Pro Video formats. Checked which files FCPX and Compressor tried to open last before crashing -> Compressor didn't seem to open any. Deleting and reinstalling everything connected to Final Cut Pro including Shared Files (manually AND with tool FCS Remover) Rebooting and testing in all kinds of "situations" Following all steps described by Apple to fix issue with Compressor ( Resolve an issue in Compressor - Apple Support) Following all steps described by Apple to fix issue with Final Cut Pro X ( Resolve an issue in Final Cut Pro X - Apple Support) After deleting Pro Video Formats everything seems to work fine but the App Store "forces" me to reinstall them. Compressor doesn't start at all or crashes instantly with a message that Compressor is corrupted and I should reinstall it. Pro Video Formats 2.0.6 (installed via App Store AND manually)Īfter installing Apple Pro Video formats via App Store Final Cut Pro X hangs while initiating libraries OR crashes when trying to set publishing format to "Computer". ![]() Compressor 4.4.1 (installed via App Store) Final Cut Pro X 10.4.3 (installed via App Store) Issue occurred on latest version of MacOS High Sierra AND macOS Mojave 10.14 Get it for PowerPC or Intel.- Macbook Pro Late 15-inch Late 2016 (perfect condition so hardware issue highly unlikely) Note that support ended for all releases listed below and hence they won't receive any further updates. You can find recommendations for the respective operating system version below. We provide older releases for users who wish to deploy our software on legacy releases of Mac OS X. The Pro Video Formats package provides support for the following codecs that are used in professional video workflows: Apple ProRes RAW and ProRes RAW HQ. Older versions of Mac OS X and VLC media player Download VLC Version 3.0.18 macOS 48 MB Devices and Mac OS X version VLC media player requires Mac OS X 10.7.5 or later. The last version is 3.0.4 and can be found here. VLC is a free and open source cross-platform multimedia player and framework that plays most multimedia files as well as DVDs, Audio CDs, VCDs, and various streaming protocols. Support for NPAPI plugins was removed from all modern web browsers, so VLC's plugin is no longer maintained. ![]() You can also choose to install a Universal Binary. If you need help in finding the correct package matching your Mac's processor architecture, please see this official support document by Apple. Note that the first generation of Intel-based Macs equipped with Core Solo or Core Duo processors is no longer supported. Previous devices are supported by older releases. It runs on any Mac with a 64-bit Intel processor or an Apple Silicon chip. VLC media player requires Mac OS X 10.7.5 or later. ![]() There's thousands of random graffiti tags in this generator. If the layers (fill-in, highlight, outline, shadow, backgrounds etc.) of the graffiti are not in the correct order, just click the. Type your name or a word in the text box above and click the Create Graffiti button. The Graffiti Tag Generator can generate thousands of ideas for your project, so feel free to keep clicking and at the end use the handy copy feature to export your graffiti tags to a text editor of your choice. We created this free graffiti generator web app to help you easily to create and draw your graffiti name or your first graffiti. How many ideas can I generate with this Graffiti Tag Generator? The Story Shack claims no copyright on any of these names, but it is of course possible that some of the values this name generator provides are already owned by anyone else, so please make sure to always do your due diligence. Do you have any other graffiti tags that you have seen that you could use for inspiration?Ĭan I use the random graffiti tags that this tool creates?. ![]()
While the title track and leadoff single crept onto the lower rungs of Billboard's Top 40, none of the album's subsequent singles charted in the States, and barely made a dent in the rest of the world.īut sales were hardly the band's biggest concern. Even after recharging with some time off - and switching labels - the band was unable to stall its worldwide commercial decline in the U.S., the album peaked outside the Top 40, and in most other territories (including their native Australia), it stalled before reaching the Top 10. If Elegantly Wasted had a happy gestation period behind the scenes, its birth was fraught with the same sales woes and personal issues that had plagued INXS in the years leading up to its release. ![]() The album was recorded in about eight days." "Many of the songs were first and second takes, just like being a bedroom production. Over nine months, very casually, on weekends here, a week there, whenever we felt like it, we were writing songs and recording them," Hutchence told the Orlando Sentinel. "Andrew and I haven't written this way in a long time. As Hutchence would later recall, although it took an extended period for the band members to find their way back together, the material fell together relatively painlessly once he and Andrew Farriss resumed regular communication, the album quickly started taking shape. ![]() With Andrew Farriss alongside veteran hitmaker Bruce Fairbairn behind the boards, INXS started work on the set of songs they'd ultimately dub Elegantly Wasted. While Hutchence slowly worked his way through his solo LP, the group landed with Mercury Records, where they started work on their 10th album in late 1996. "It just seemed like the logical time to take a break." This helped to create a situation resulting in a lot of personal and business friction within the band, as well as the record label," Hutchence explained. As a band, we've recorded an album every 12 to 18 months over the last five or six years. "We really wanted to get off the old carousel for a while. It all contributed to an air of exhaustion around the group and slowed their return after the conclusion of their longstanding association with Atlantic Records following the relative failure of the Full Moon, Dirty Hearts LP. Multi-instrumentalist Kirk Pengilly was working his way through a divorce after a brief marriage to singer Deni Hines, and the Farriss brothers - bandleader Andrew, drummer Jon, and guitarist Tim - suffered the death of their mother. ![]() Hutchence's troubles earned the most attention, but much of the INXS lineup was coping with some sort of turbulence or emotional trauma during this period. There was a period when it seemed like the group's break might end up being permanent. Singer Michael Hutchence, who'd already dabbled in extracurricular activity with his Max Q side project in 1989, started working on a full-fledged solo LP in the years after Full Moon, Dirty Hearts, and his tabloid-friendly lifestyle - including his affair with Paula Yates, then the wife of Boomtown Rats frontman Bob Geldof - only furthered his reputation as a debauched star. ![]() #NotShowIn=Unity # <- comment out this line !Įxec=nautilus -new-window / # <- adjust ! #OnlyShowIn=Unity # <- comment out this line ! MimeType=inode/directory application/x-gnome-saved-search Keywords=folder manager explore disk filesystem Ĭategories=GNOME GTK Utility Core FileManager There you can adjust the Exec= line with the desired directory. So add the entry NotShowIn=Unity to / and comment it out in sktop. Maybe it is possible to provide nautilus the desired directory through dbus ( /usr/share/dbus-1/services/) but I am not familiar with that system in detail.Ī simple solution for me was to hide the gnome/dbus launcher-icon and make the old one visible again. The problem is an entry DBusActivatable=true that makes the system to run nautilus via dbus. The file that is shown in unity-dash is not anymore /usr/share/applications/sktop but /usr/share/applications/.Ĭhanging the Exec= line in the file itself does not have any effect. I don't know know about any side effects of this latter step, I hope it's gonna be fine in the long run.Įither reboot or just log out of the session and log back in.įor me now it opens my directory both when called via the dash and when clicked in the dock. Note that I removed the %U from the end of the line.ĭeal with the DBusActivatable entry (thanks 元1N).Įither assign a false value to it, or comment out the line, like this: # DBusActivatable=true Edit both lines so they look like this: Exec=nautilus -new-window /your/desired/directory There are two lines that start with Exec=. Or by right-clicking the icon → Properties → Permissions tab → checkbox Allow executing file as program. Make the copy executable, either with: chmod +x /home//.local/share/applications/ (Worth noting that while on the UI the app is called "Files", under the hood it's still referred to as nautilus.)Ĭopy the right launcher to the right location: /usr/share/applications/ Here is what worked for me on a vanilla Ubuntu 20.04: Is there a simple way that I can configure an icon in the launcher bar to run this command and have the Nautilus icon that looks like a metal file drawer? Note: if I enter nautilus /home/judy/Documents from the command line, Nautilus properly opens in the desired directory. I've also edited the file, just to be sure, with no joy. I've edited every file to read as follows: Exec=nautilus -new-window /home/judy/Documents I've checked all the files after editing them to make sure that I saved the edit effectively, and all look good to me. I've edited all the variants of sktop in the said directory, but none of the edits has an effect. I've scoured this site and found answers instructing users to edit the /usr/share/applications/sktop file, replacing %U with the path to the desired default directory. How do I configure Nautilus to open at my Documents folder instead of my home folder? For example, a level 1 cotton mill requires one beer to flip. To sell cotton, pottery, or manufactured goods to these traders, you must also "grease the wheels of industry" by consuming beer. Each of these traders is looking for a specific type of good each game. You must now sell your product through traders located around the edges of the board. Iron, coal, and cotton are three industries which appear in both the original Brass as well as in Brass: Birmingham.īrewing has become a fundamental part of the culture in Birmingham. This provides players with the opportunity to score much higher value canals in the first era, and creates interesting strategy with industry placement. Instead of each flipped industry tile giving a static 1 VP to all connected canals and rails, many industries give 0 or even 2 VPs. VPs are counted at the end of each half for the canals, rails and established (flipped) industry tiles.īirmingham features dynamic scoring canals/rails. The game is played over two halves: the canal era (years 1770-1830) and the rail era (years 1830-1870). (This action replaces Double Action Build in original Brass.) ![]() ![]() ![]() Birmingham tells the story of competing entrepreneurs in Birmingham during the industrial revolution, between the years of 1770-1870.Īs in its predecessor, you must develop, build, and establish your industries and network, in and effort to exploit low or high market demands.Įach round, players take turns according to the turn order track, receiving two actions to perform any of the following actions (found in the original game):ġ) Build - Pay required resources and place an industry tile.Ģ) Network - Add a rail / canal link, expanding your network.ģ) Develop - Increase the VP value of an industry.Ĥ) Sell - Sell your cotton, manufactured goods and pottery.ĥ) Loan - Take a £30 loan and reduce your income.īrass: Birmingham also features a new sixth action:Ħ) Scout - Discard three cards and take a wild location and wild industry card. Brass: Birmingham is an economic strategy game sequel to Martin Wallace' 2007 masterpiece, Brass. ![]() PHPMailer supports sending templates emails at ease. This would be where you would make the changes that need to be made on each page. A templated email uses HTML and CSS styling to make it look appealing to users. Then your individual pages would be like this: Is there a way I can put this in template.htm (or something similar) and have php or javascript code take this and insert everything from the requested file inside of the tag? I don't know a lot of php, so this is probably a piece of cake for you gurus, but I would appreciate the help. I think it's kind of stupid to copy-paste all this into each document, and painstakingly go in and change each page separately if I just want to change one word or tag. To use an HTML file as an email template, simply read it as a string and put it into the PHP mail function: to '' subject 'Test' body filegetcontents ('template.html') head 'MIME-Version: 1.0\r ' head. An example wrapper to allow you to escape data to html function. So, I'm making a site about WWI as a school assignment, and I want this to appear in every document: An easy-to-read, quick reference for PHP best practices, accepted coding standards. ![]() Thanks BBB and reddit for the help on fighting Samsung on this issue. Well, today I just got notification that Samsung did not want to go into arbitration and refunded my full amount. they said they would find a third party arbitrator in the mean time to handle this issue with Samsung. Well just 2 weeks ago I faxed in the form accepting arbitration against Samsung. So I proceeded to the BBB (Better Business Bureau) filed a complaint against Samsung and posted my pictures and let it be, after about a month of back and forth with Samsung about this issue, BBB decided enough was enough and asked if I would like to go to arbitration. I even showed them all 9 of my photos and still were denying my charge back request. They basically gave me a run around and was then led to the online customer e commerce team which still denied me a refund. I was then able to contact customer service and explain the situation and that I had photos. ![]() So Samsung decided to charge back 275 dollars of the 300 they originally offered me. The pictures I have contradict the photo they took and sent me. It was a damaged housing around the charging port on the phone. However once Samsung received the device they found damage, so they sent me a picture of the damage. I was taking advice of others on this very Reddit about taking pictures before sending in the device for review. I got a galaxy s9 and traded in my old device to Samsung and was offered 300 dollars. So I been dealing with this for almost 2 months now. Other: If it doesn't fall in any of the other categories, post it here!.Tricks: Neat tricks or if you discover something that you want to share.Discussion: for discussion about Samsung or Samsung's products.Rumor: for rumors about Samsung or Samsung's products.News: for news about Samsung or Samsung's products.Link flair must be used (this prevents spam) No Offensive, Harassing or Inflammatory Language.No tech-support or “what should I buy” questions.No self-promotion (including referral links/codes).No posts that aren't directly related to Samsung.Posts must foster reasonable discussion.Join the official r/Samsung Discord Rules Those people are getting a little bit of lift, but mostly what they're getting is the relief from these symptoms that are about to come down on them. One of the things you learn when you take a caffeine fast, as I did, is that the experience of caffeine is very different to a caffeine virgin or a restored caffeine virgin, as I was, than it is to someone who's addicted. It's the suppression of the symptoms of withdrawal. And then they have that cup of coffee, and the pleasure they're getting from it, I learned, is not simply the lift, the euphoric lift of the drug. They're starting to feel a little off - that muzziness is coming in. All those people who tell you, "I'm not civil" "I'm not fit for human conversation until I have a cup of coffee" - they're beginning to go through that withdrawal. I mean, you haven't had coffee or tea since sometime the day before. And this is the subtle and, perhaps, insidious effect it's having on you. So, for example, the caffeine you ingest at noon - a quarter of it is still circulating in your bloodstream at midnight. And coffee or tea cuts into that, even if you stop drinking it, say, at noon, because caffeine has a very long half-life and quarter-life. ![]() As we get older, we have less of it naturally. Matt Walker, the psychologist who wrote Why We Sleep, thinks that this is very important to our health to have sufficient amounts of deep sleep. It's like cleaning up the desktop on your computer at the end of the day. It's where you kind of take memories from short-term working memory and put them in their proper place. It's where these slow waves start radiating from the front of your brain into the back, and they kind of harmonize all the neurons, get them on the same page. This is a really deep place you go for not that long a part of the night, but it's really important to your mental and physical health. This isn't REM sleep, where you're having dreams, or light sleep. And specifically, one very particular kind of sleep, which I'd never heard of before, called "slow wave" or deep sleep. It's a problem in ways we don't perceive, because caffeine undermines the quality - not necessarily the quantity, but the quality - of our sleep. Shots - Health News How Deep Sleep May Help The Brain Clear Alzheimer's Toxins And loss of confidence is actually listed as one of the symptoms of caffeine withdrawal." The whole book seemed like a really stupid idea. It was only when he quit caffeine cold turkey that Pollan fully appreciated the mental and psychological boost his morning cup of coffee had provided: "I just couldn't focus," he says. "If you have a cup of coffee after you've learned something or read a textbook chapter, you are more likely to test better on it the next day." "There are studies that show that people's both mental performance and athletic performance are improved by coffee," he says. ![]() Caffeine, he says, is a powerful drug that alters the brain in surprising ways. Pollan's new audiobook, Caffeine, explores the science of caffeine addiction and withdrawal - and the broader impact that coffee and tea have had on the modern world. "I thought, 'Why not explore that relationship?'" We never think about it as a drug or an addiction, but that's exactly what it is," Pollan says. "I had some great sleeps." But he didn't realize that a temporary "loss of confidence" and lack of focus were withdrawal symptoms.Īfter wrapping up his book about the potential therapeutic benefits of psychedelic drugs, author Michael Pollan turned his attention to a drug that's hidden "in plain sight" in many people's lives: caffeine. "I recommend it," he says of his time without the drug. Michael Pollan gave up caffeine entirely for three months while working on his audiobook, Caffeine. |
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